منابع مشابه
Glucose-induced conformational change in yeast hexokinase.
The A isozyme of yeast hexokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) crystallized as a complex with glucose has a conformation that is dramatically different from the conformation of the B isozyme crystallized in the absence of glucose. Comparison of the high-resolution structures shows that one lobe of the molecule is rotated by 12 degrees relative to the other lobe, resulting in ...
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The cytoplasmic surface topography of purple membranes imaged by the atomic force microscope depends mainly on the force applied to the stylus. Imaged at forces of 300 pN, individual bacteriorhodopsin molecules reveal two domains. The resulting donut-shaped trimers reversibly transform into structures exhibiting three prominent protrusions when scanned at 100 pN. In parallel, the height of the ...
متن کاملCalcium-induced calmodulin conformational change. Electrochemical evaluation.
Calmodulin (CaM) is an essential protein present in all eukaryote cells, ranging from vertebrates to unicellular organisms. CaM is the most important Ca2+ signalling protein, composed of two domains, N- and C-terminal domains, linked by a flexible central α-helix, and is responsible for the regulation of numerous calcium-mediated signalling pathways. Four calcium ions bind to CaM, changing its ...
متن کاملPotentiometric titration and conformational change in pepsinogen.
Potentiometric titrations of pepsinogen as functions of ionic strength and temperature were studied. It was found that the ionic strength has a minor effect on the titration behavior of the protein. The maximum values of the buffering capacity in the pH range of 6.0 to 9.0 were found at pH values corresponding to those at which a conformational change of the protein occurs as determined by opti...
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Carbohydrate-binding proteins occur widely in the plant kingdom. These proteins, commonly derived from seeds, are called phytohemagglutiuins or lectins (reviewed by Sharon and Lis’). It has become increasingly apparent that lectins can serve as probes for carbohydrate structure and function. The jack-bean lectin, namely, concanavalin A (con A), has received considerable attention because of its...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2002
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri869